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KMID : 0358420080510070744
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Korean Journal of Obstetrics and Gynecology
2008 Volume.51 No. 7 p.744 ~ p.749
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The clinical implications of acquired thrombophilia in patients with ovarian hyperstimulation syndrome
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Kim Sun-Min
Kim Jae-Won
Jee Byung-Chul
Suh Chang-Suk
Kim Seok-Hyun
Lee Hyun-Ui
Youn Jung-Min
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Abstract
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Objective: To investigate the clinical significance of thrombophilia in patients admitted with ovarian hyperstimulation syndrome (OHSS).
Methods: Twenty-five infertile women who were admitted into university hospital due to OHSS after ovarian hyperstimulation for intrauterine insemination or in vitro fertilization. Blood samples were drawn at the time of admission and three thrombophilic factors were assayed; antithrombin III, protein C and protein S. Subjects were divided into severe (n=18) and mild-to-moderate (n=7) OHSS, and laboratory parameters including three thrombophilic factors were compared.
Results: Antithrombin III level was abnormal in 40% of subjects, protein C in 12%, and protein S in 72%. There was no significant difference in the laboratory parameters between the patients with normal (n=15) and abnormal antithrombin III levels (n=10). However, the patients with abnormal antithrombin III levels had significantly more severe OHSS than those with normal value (100% vs 55.6%, P=0.013). The patients with at least one abnormal thrombophilic factor had significantly more severe OHSS than those with all normal value (94.4% vs 42.9%, P=0.012).
Conclusions: Thrombophilic factors, particularly antithrombin III, may be associated with disease severity in patients with OHSS.
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KEYWORD
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Ovarian hyperstimulation syndrome, , Thrombophilia, Antithrombin 3
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